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KMID : 1149220080160020229
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Korean Journal of Oriental Medical Prescription
2008 Volume.16 No. 2 p.229 ~ p.241
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Ulmi Cortex Prevents Cisplatin-Induced Apoptosis in Mice
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Moon Mi-Hyun
Jeon Ji-Young
Lee Seon-Ah
Shin Yong-Jin
Ko Seok-Jae
Moon Goo
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Abstract
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Objectives : The purpose of this study is to investigate the effect of Ulmi Cortex(UC) on the cisplatin-induced cell death.
Materials and Methods : I examined several kinds of cell populations such as T cells, T cells, macrophages and dendritic cells in spleen.
Result : When cisplatin was injected to mice, UC recovered total number of cells in spleen and also the number of T cells, macrophages and dendritic cells. UC also effected the activation of and T cells such as , cells. To further investigate the effect of UC on the cisplatin-induced cell death, I examined the death of splenocyte and total T cells. UC inhibited cisplatin-induced cell death.
Conclusion : Taken together, my results suggest that UC may be a beneficial oriental medicine for side effects during anti-tumor therapy.
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KEYWORD
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Ulmi Cortex, cisplatin-induced cell death, macrophages, dendritic cells. T cells(, , , )
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